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Article summary:

1. Autism spectrum disorder (ASD) is characterized by alterations in social, communicative, and stereotyped behaviors, but the molecular basis of these behaviors remains unclear. Dysregulation of neurotransmitters, cellular metabolism, and immune signaling have been implicated in ASD etiology.

2. Maternal autoantibody-related (MAR) ASD is a phenomenon where ~20% of mothers of children subsequently diagnosed with ASD possess circulating autoantibodies directed against proteins important for early development. Exposure to clinically relevant patterns of these autoantibodies has been shown to result in changes to behavior, brain structure, and neural progenitor cell proliferation in mice.

3. In this study, an endogenous model of MAR-ASD exposure was created in rats to examine the effects on offspring across the lifespan. Offspring exposed to MAR-ASD autoantibodies displayed altered trajectories of brain growth and changes in ASD-relevant behavioral outcomes. Longitudinal structural magnetic resonance imaging (sMRI) and magnetic resonance spectroscopy (MRS) were used to examine brain structure and metabolite levels within a specific recording voxel placed in the frontal cortex of rat offspring.

Article analysis:


首先,该文章没有探讨其他可能导致自闭症的因素,例如环境污染、药物暴露等。其次,该文章只使用了大鼠模型进行实验,并未涉及人类实验或其他动物模型。此外,该文章没有提供足够的证据来支持其主张,例如认为MAR-ASD aAb会导致大脑生长轨迹改变和ASD相关行为结果改变。